Uvod - lijekovi za suzbijanje boli u leđima

In this article, several classes of commonly prescribed drugs for the treatment of low back pain will be considered. For each agent or group of agents considered, mechanisms of action, efficacy and current clinical research, dosing and cost, and complications and contraindications will be discussed.

Acetaminofen korišten za suzbijanje boli u leđima

Acetaminophen (Tylenol®) is the principle member of the group of drugs classified as para-aminophenol derivatives. While acetaminophen's analgesic and antipyretic (fever reducing) effects are equal to those of aspirin, its anti-inflammatory effects are weak. Its therapeutic effects appear to be secondary to an inhibition of prostaglandin (mediators of inflammation) biosynthesis with a resultant increase in the pain threshold and modulation of the hypothalamic heat-regulating center (a part of the brain that activates part of the nervous system).

Protu-upalni lijekovi korišteni za suzbijanje boli u leđima

The primary mechanism of action in NSAIDs is a reduction of cyclooxygenase (enzymes that make prostaglandins) activity and a resultant decrease in prostaglandin synthesis. Prostaglandins are active mediators of the inflammatory cascade, which also serve to sensitize peripheral nociceptors (nerve endings). A reduction in their local concentration could therefore explain the combined anti-inflammatory and analgesic properties of NSAIDs.

Lijekovi za opuštanje mišića korišteni za suzbijanje boli u leđima

The muscle relaxing properties of "muscle relaxants" arise not from direct activity at the muscular or neuromuscular junction level but rather from an inhibition of more central polysynaptic neuronal (nerve cells that end in synapses) events. These agents have also been shown in some studies to demonstrate superior analgesia to either acetaminophen or aspirin, and it remains uncertain if muscle spasm is a prerequisite to their effectiveness as analgesics.

Opijati korišteni za suzbijanje boli u leđima

Opioids occupy the second rung on the World Health Organization (WHO) analgesic ladder in the treatment of moderate to severe cancer pain and are commonly prescribed for postoperative pain, where they have been found to successfully treat both local and more generalized pain symptoms.

Kortikosteroidi korišteni za suzbijanje boli u leđima

Oral steroids have been found effective in the treatment of inflammatory reactions associated with allergic states, rheumatic and autoimmune diseases, and respiratory disorders. Corticosteroids interact with receptor proteins in target tissues to reg...

Kolhicin korišten za suzbijanje boli u leđima

Colchicine has been regarded by some as the most powerful anti-inflammatory agent known to man. The beneficial effects of colchicine in the treatment of gout are apparently secondary to its ability to inhibit both the metabolic and phagocytic activity and migration of granulocytes. Colchicine's inhibition of the release of histamine containing granules from mast cells is also believed secondary to its interference with granule transportation by the microtubular system.

Anti-depresivi korišteni za suzbijanje boli u leđima

While several classes of anti-depressants have been used successfully in the treatment of a variety of pain syndromes, the literature most strongly supports the analgesic efficacy of the tricyclics (anti-depressant drug). Amitriptyline (a type of ant...

Zaključak: Akutna bol u leđima i lijekovi

Zaključak o akutnoj boli u donjem dijelu leđa i korištenju lijekova.